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Opioid-induced hyperalgesia after implantation of intrathecal morphine pump: a case report
Med Biol Sci Eng 2020;3(2):47-51
Published online July 31, 2020
© 2020 Medical Biological Science and Engineering.

Sungryul Yoon1, Rakmin Choi2, Jaedo Lee1, Jongchan Won1, Bousung Lee1, Kwanghaeng Lee1, Dongseok Kim1, Jaeyoung Yang1

Department of Anesthesiology and Pain Medicine, 1Veterans Health Service Medical Center, Seoul, 2Armed Forces Capital Hospital, Seongnam, Korea
Correspondence to: Jaeyoung Yang
Department of Anesthesiology and Pain Medicine, Veterans Health Service Medical Center, 53 Jinhwangdo-ro 61-gil, Gangdonggu, Seoul 05368, Korea
Tel: +82-2-2225-1473
Fax: +82-2-2225-1946
Received March 6, 2020; Revised April 10, 2020; Accepted May 28, 2020.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Opioid-induced hyperalgesia is characterized by an increased pain response to noxious stimuli despite increased use of opioid medications. Here, we report the case of a 43-year-old woman diagnosed with post-laminectomy syndrome who presented with an increasing pain score following a morphine infusion via an implanted intrathecal drug delivery device. Her pain improved after reducing opioid doses and the administration of intravenous ketamine infusion therapy. Thus, the early suspicion of opioid-induced hyperalgesia is essential for patients with increasing pain refractory to augmented doses of opioid medications.
Keywords : Hyperalgesia; Implantable; Intrathecal; Ketamine; Morphine; Opioid
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